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What is Acyclovir? Acyclovir is antiviral drug that is active against viruses Herpes simplex type 1 and 2, Varicella zoster, Epstein-Barr virus. Acyclovir is used to treat sensitive to the medication viral infections: herpetic infections of the skin and mucous lining (cold sore, genital herpes), shingles, herpes zoster including patients with immunodeficiency. Acyclovir is made by many pharmaceutical companies like Cipla (Acivir), Ranbaxy, Zydus, Starmed (Medivir). Acyclovir comes in the form of oral tablets Acyclovir 800mg, 400mg and 200mg. How does Acyclovir work? Acyclovir is an antiviral agent (virostatic), acyclic guanine analogue, natural component of DNA, a synthetic nucleoside analogue of thymidine. After oral administration Acyclovir under the action of the enzyme thymidine kinase is converted into its active form acyclovir triphosphate. Acyclovir triphosphate penetrates infected by herpes virus cells and inhibits DNA polymerase. Then competitively substitutes deoxyguanosine triphosphate in the synthesis of DNA viruses. By embedding in the synthesized virus DNA acyclovir triphosphate blocks the multiplication of the virus. The high selectivity and low toxicity to humans is associated with absence of thymidine kinase in healthy human cells. The specificity and very high selective actions is also connected with its accumulation in cells infected by herpes virus. Acyclovir is active against herpes simplex virus Herpes simplex types 1 and 2, the virus that causes chickenpox and Varicella zoster, Epstein-Barr virus. Acyclovir is moderately active against cytomegalovirus. In patients with Herpes infection, Acyclovir helps prevent the formation of new elements of rashes, reduces the likelihood of cutaneous dissemination and visceral complications, speeds up the formation of crusts, reduces pain in the acute phase of herpes zoster, posesses immunostimulatory effect. Which is Acyclovir pharmacokinetics? After oral administration nearly 20% of acyclovir is absorbed into the blood circulation. Only a very small amount of Acyclovir binds to plasma proteins. The concentration of acyclovir in cerebrospinal fluid is approximately 50% of its concentration in plasma. Acyclovir penetrates hemato-placental barrier, is excreted with breast milk. The active metabolite of Acyclovir is 9- carboxymethoxymethylguanine (CMMG). Acyclovir is excreted with urine in unchanged form and in the form of metabolites. The average half-lafe period is 3 hours. What is Acyclovir used for? · Infections of skin and mucous linings caused by Herpes simplex virus types 1 and 2, both primary and recurrent (including herpes labialis, genital herpes, acute primary genital infection). · Treatment of infections caused by viruses Varicella zoster (including chickenpox, shingles, herpes zoster). · Treatment and prevention of infections of the skin and mucous linings caused by Herpes simplex virus types 1 and 2 in patients with immunodeficiency. How Acyclovir is taken? Acyclovir for oral administration comes in in the form of Acyclovir 200mg, Acyclovir 400mg and Acyclovir 800mg tablets. Tablets should be taken whole swallowing with sufficient amount of water. Do not chew, crash or split the tablets unless it is prescribed by your doctor. The recommended dose for patients with herpes labialis is Acyclovir 200mg 5 times daily (every 4 hours) for a period of 5 days. The treatment should be started as soon the the first symptoms of the disease occur. When Acyclovir oral is contraindicated? · Known reactions of allergy and hypersensitivity to any of the drug ingredients · Pregnancy (Acyclovir oral is a pregnancy category B meaning that is probably safe to use it during pregnancy. However, the full risk is unknown. Make sure to consult your doctor if you are pregnant or breastfeeding.) · Breastfeeding A condition called thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) has been reported in some patients taking acyclovir 800mg, 400mg and 200mg. Seek immediate medical attention if you develop any of the following symptoms during the treatment: · bruising of unknown origin · bleeding of unknown origin · fever High doses of the medication such as Acyclovir 400mg and Acyclovir 800mg should be used with caution in elderly patients, patients with liver dysfunction, electrolyte balance disorders and hypoxia. Which Acyclovir side effects are possible during the treatment? Acyclovir is usually well tolerated and side effects are not common. Generally Acyclovir may cause the following side effects: allergic reaction in the form of skin rashes, itching, hives, urticaria. In rare cases : nausea, vomiting, diarrhea, elevated levels of bilirubin in the blood, increased level of liver enzymes, elevated levels of urea, hypercreatininemia, headache, dizziness, fatigue, reduced concentration, hallucinations, drowsiness or insomnia, a slight deterioration of hematological parameters (eritropeniya , leukopenia), fever, alopecia. How Acyclovir can interact with other medicines? · The medication can interact with uricosuric drug (probenicid) · Acyclovir may reduce the level of phenytoin in the blood making the medication less effective · Acyclovir can increase the level of tenofovir in your blood and thus increases the risk of tenofovir side effects
You can buy Acyclovir online at our reliable online pharmacy. We offer only high quality products for the lowest prices. How can I buy Acyclovir 800mg, 400mg or 200mg? You can buy Acyclovir oral tablets using Visa/Visa Electron card and E-check (ACH, Check21) Which is the manufacturer of Acyclovir? Acyclovir is made by many pharmaceutical companies like Cipla (Acivir), Ranbaxy, Zydus, Starmed (Medivir). Acyclovir comes in the form of oral tablets Acyclovir 800mg, 400mg and 200mg