Allegra. Generic Allegra (fexofenadine oral). Buy Allegra online
Brand name: Allegra
Generic name: Fexofenadine hydrochloride (active ingredient)
What is generic Allegra?
Allegra contains the active ingredient Fexofenadine which a 3rd generic of anti-histamine medicine. Fexofenadine oral is indicated to treat a wide variety of symptoms associated with allergy. Allegra is highly effective in the following conditions: running nose, sneezing, hay fever, hives, watery eyes, redness and irritation of the eye and nose mucous lining. Generic Allegra means that medication (which contains the same active ingredient) is therapeutically equal to a brand drug. Action mechanism, indications, contraindications, side effects, contraindications are the same. The difference between Allegra brand and generic consists in pharmaceutical formulations, excipients, shape and form of tablets. Pharmacokinetic characteristics may differ as well.
How does Fexofenadine oral work?
Fexofenadine oral is an H1 histamine receptor blockers; active metabolite of terfenadine. Fexonadine is a racemic mixture of two pharmacologically active isomer.
Fexofenadine is a highly specific inhibitor of H1-receptor. It's affinity to H1 receptors is much higher than tefenadine. By inhibiting H1 receptors Fexofenadine prevents the effects of histamine (inflammatory mediators). Histamine is released from the mast cells and basophills in response to allergic reaction and causes some of allergy symptoms (like sneezing, itching and rhinorrhea). In addition, Fexofenadine stabilizes the membrane of mast cells, reduces the release of histamine and other biologically active substances.
Fexofenadine does not possess any other pharmacological activity. It does not exert anticholinergic, adrenergic, analgesic, antispasmodic and antidepressant activity.
Fexofenadine does not affects slow calcium channels and therefore does act change QT interval. Allegra does not affect the central nervous system, does not possess sedative action and effects of psychomotor reaction even at doses higher than recommended.
Anti-allergic action is achieved in one hour after oral administration and reaches its maximum in 6 hours. A therapeutic effect lasts nearly 24 hours. The medication can be used for a long time without causing drug tolerance.
Which is Allegra pharmacokinetics?
Fexofenadine is rapidly absorbed from the gastrointestinal tract if taken orally, reaching its peak plasma concentration (Cmax) after 1-3 hours. The average bioavailability of the medication is 33%. Food intake does not affect the absorption of Allegra. Fexofenadine binds to plasma proteins by 60-70%. The medication does not penetrate blood-brain barrier. Fexofenadine oral is metabolized in the liver and is eliminated with faeces (90%) and urine (10%). Half life period is 11-15 hours. Liver's pathology has a little effect on the absorption and elimination of fexofenadine oral. There is no need to correct the dose for patients with liver diseases.
When is Allegra prescribed?
Generic Allegra (fexofenadine) is prescribed for the treatment of:
- Allergic rhinitis, hay fever
- Chronic idiopathic hives, allergic urticaria (chronic urticaria), recurrent Quincke's edema (angioedema)
How is generic Allegra (fexofenadine) taken?
The right Allegra dosage is based on several health conditions such as: patient's age, allergy and their severity, other health problems, concomitant drug's therapy. Consult your health care provider to adjust the corresponding Allegra dosage for you. Usually the recommended dose in hay fever for adults and children over 12 years of age is 2 tablets 60mg twice daily or 1 tablet 120 mg or 180mg once daily. Fexofenadine oral (Allegra) is available in the form of tablets and should be taken with full glass of water. Do not take Allegra with a milk or fruit juice. Use the medicine exactly as prescribed by your doctor. If you missed Fexofenadine(Allegra) dose take it as soon as possible. Do not take two Allegra tablets at the same time.
Allegra (Fexofenadine) precautions and warning!
Fexofenadine should not be used in: increased sensitivity to any of the medication ingredients or known intolerance of any Allegra constituents. Fexofenadine is contraindicated in children less than 6 years of age and should be used with caution in children between 6 and 12 years.
Allegra tablets should not be used if you pregnant and in breastfeeding mothers. Allegra belongs to pregnancy category C meaning that it is unknown how the medicine can affect an unborn child.
Let your health care provider know if you have severe kidney (kidney failure) or liver diseases.
Allegra may cause some health care problems that are uncommon, however some patients may experience dizziness and in very rare cases drowsiness. Consult your doctor if you noticed first signs of these conditions.
The medication should be used with caution in elderly patients.
Allegra may change the results of certain skin tests.
Fexofenadine oral may cause drowsiness. That is why it is not recommended to drive or operate any machinery while the treatment
Which are Allegra side effects?
Like other drugs Allegra may cause some side effects. However these side effects are not severe and usually pass away in some days. The most common fexofenadine side effects include: vomiting, headache or migraines, cough, diarrhea, airways infection, drowsiness or dizziness, ear infection known as otitis media, dyspepsia, neck and back pain. In some cases patients may complain on different skin reactions. Such as itching, skin rash, hives.
If you are experiencing severe side effects during the treatment with Fexofenadine, seek medical attention immediately. Usually the medication is well tolerated and doesn't cause any severe side effects.
Can Allegra cause weight gain?
According to the results of clinical trials Allegra (fexofenadine oral) does not weight gain. If you notice weight gain while taking Fexofenadine, consider the following advices:
· Practice enough sports
· Eat a healthy diet reach in fibres, vitamins and minerals
· Limit alcohol drinking
Can Fexofenadine oral cause Insomnia?
Postmarketing investigations showed that Allegra can cause Insomnia in some patients. Patients taking Allegra may experience the following symptoms of insomnia:
· Problems with falling asleep
· Waking up frequently during the night and having difficulty falling asleep again
· Waking up too early in the morning
Can Allegra cause back pain?
According to the results of clinical trials back pain is one of the common Allegra side effects. To relieve back pain a patient can take certain medications like NSAID's or applying cold or heat to the affected area.
Can Allegra cause migraine headache?
Yes. Clinical trials showed that nearly 10% of all patients taking fexofenadine can have migraine headache. If you develop migraine while the treatment make sure to inform your health care provider.
Which are Fexofenadine overdose symptoms?
Do not take the medicine at dose higher than recommended. The symptoms of Allegra overdose symptoms may include: drowsiness, tiredness, dry mouth.
Which are Allegra drug interactions?
Be sure to let your doctor know if you are taking any medications including prescription, over-the-counter preparation or herbal supplements. Some clinical investigations has shown that Allegra that interact with ketaconazole(Nizoral) and Erythromycin(ERY). These medicines may change the drugs metabolism and increase fexofenadine blood levels.
Antacids make the medicine less effective. Use Antacid preparation 2 hours before or after Allergra tablets were taken.
Allegra should not be used with any fruit juices.
How the medication should be stored?
Fexofenadine oral should be stored at dry and protected from light place out of reach of children. Do not store in a bathroom.
Where can I buy Allegra online?
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Which are manufacturers of generic Allegra?
Generic Allegra is made by different manufacturers such as:
- Dr. Reddy's Laboratories
- Mylan Pharmaceuticals
- Aventis Pharma
- Prasco Laboratories
- Teva Pharmaceuticals.
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