Augmentin oral. Augmentin 875-125mg. Buy Augmentin generic
What is generic Augmentin?
Augmentin oral is a combined bactericidal broad-spectrum antibiotic. It is used to treat bacterial infections caused by susceptible microorganisms such respiratory tract infections and ENT infections (otitis media, sinusitis, tonsillitis, pharyngitis, bronchitis, pneumonia, bronchopneumonia), infections of the skin and soft tissue (abscess, cellulitis, wound infection), urinary tract infections (cystitis, urethritis, pyelonephritis, salpingitis, endometritis, vaginitis, gonorrhea), osteomyelitis, sepsis, peritonitis, postoperative infections. Generic Augmentin oral contains 2 main ingredients Amoxicillin (250mg, 500mg and 875mg) and clavulanic acid (125mg). Generic Augmentin means that medication contains the same active ingredients and dosage as brand medication has and therefore the effects, indications, contraindications are the same.
How does Augmentin work?
Amoxicillin and Clavulanic acid (clavulonate potassium) are combined antibacterial medication that belongs to a group of antibiotics called semisynthetic penicillins (protected penicillins). Amoxicillin is a broad spectrum penicillin antibiotic that exerts bactericidal effect against a wide variety of microorganism. Action mechanism is associated with suppressing the synthesis of peptidoglycan in bacterial cell walls during the growth phase of the microorganisms through competitive inhibition of transpeptidase. Clavulanic acid possesses only a weak antibacterial activity, but irreversibly binds to beta-lactamases (forms a stable complex with them), thereby protecting amoxicillin from enzymatic destruction, and provides a guaranteed opportunity to display its antibacterial action.
Clavulanic acid inhibits beta-lactamase II-V-type classification of Richmond-Sykes. Such enzymes are produced by gram-positive and gram-negative, including anaerobic microorganisms such as Staphylococcus spp., Haemophilus influenzae, Moraxella catarrhalis, Klebsiella spp., Escherichia coli, Neisseria spp., Proteus spp., Yersinia enterocolitica, Bacteroides spp.
Clavulanic acid is not active against beta-lactamase type I, produced by Enterobacter spp., Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp.
Bactericidal effect covers a broad spectrum of gram-positive and gram-negative aerobic and anaerobic pathogens including the following microorganisms:
Gram-positive:
Streptococcus Group A, B, C, G (Strep. pneumoniae, viridans, milleri, faecalis, pyogenes, anthracis, agalactiae, bovis); Staphylococcus aureus, epidermidis (penicillin-susceptible and penicillin-resistant but methicillin-resistant strains of MRSA, MRSE ); Enterococcus faecalis ; Corynebacterium spp.; Listeria monocytogenes; Nocardia asteroides;
Gram-negative:
Aeromonas spp.; Bordetella pertussis; Brucella spp.; Campylobacter jejuni, coli; Citrobacter spp. (Moderately susceptible); Escherichia coli; Gardnerella vaginalis; Haemophilus influenzae; Helicobacter pylori; Klebsiella spp., K. pneumoniae; Moraxella catarrhalis; Morganella spp. (Moderately susceptible); Neisseria gonorrhoeae, meningitidis; Pasteurela multocida; Proteus mirabilis, vulgaris; Salmonella spp.; Shigella spp.; Vibrio cholerae; Yersinia enterocolitica (moderately susceptible); Branhamella catarrhalis.
Anaerobic:
Actinomyces israeli; Bacteroides spp. (Including B. fragilis); Prevotella melaninogenica; Clostridium spp. (Except Cl. Difficile); Peptostreptococcus spp.; Eikenella corrodens; Fusobacterium spp.; Propionibacterium spp.; Peptococcus spp.
Other:
Mycobacterium tuberculosis, fortuitum, bovis, kanasaii - moderately susceptible, (M. chelonei - stable); Treponema pallidum; Nocardiae spp., Leptospirae spp.
The following microorganisms are resistant or partially resistant: Pseudomonas aeruginosa, Enterobacter spp., Serratia spp., Proteus rettgeri, morganii, Providencia spp., Mycoplasmae spp., Chlamidiae spp., Rickettsiae spp
Which is Augmentin oral pharmacokinetics?
Clavulanic acid is combined with amoxicillin because the pharmacokinetic parameters of both components are similar and in combination they do not affect the pharmacokinetics of each other.
Absorption:
Both components are rapidly absorbed after oral administration. Simultaneous food intake does not affect the absorption. Peak plasma concentrations are reached after about 45 minutes after ingestion.
Distribution:
Bioavailability of amoxicillin is approximately 90%. Bioavailability of clavulanic acid is approximately 60%. Amoxicillin and Clavulanic acid bind to plasma proteins by 17-20% and 22-30%, respectively.
Both components are well distributed in tissues and interstitial fluid - the high concentration of the drug found in plasma, sputum, bronchial secretion, lung tissue, the middle ear, prostate, peritoneal abscess, gall bladder, uterus, ovary, adipose tissue, muscles, bones, skin, biological fluids (including in the synovial, peritoneal, pleural, bile, purulent discharges).
Metabolism, excretion:
Amoxicillin is substantially excreted by the kidneys by tubular secretion and glomerular filtration. Clavulanic acid is actively metabolized in the liver and excreted by glomerular filtration and partially in the form of metabolites. Patients with severe renal or hepatic insufficiency require correction of dosing regimen (reduced dosage and/or increase the interval between doses), because clearance is decreased.
What is Augmentin oral is used for?
Augmentin is used in the treatment of infectious diseases caused by susceptible microorganisms:
· Infections of the upper and lower respiratory tract, ear, nose and throat infections: sinusitis, tonsillitis, otitis media, acute and chronic bronchitis, aspiration pneumonia, bronchopneumonia, empyema, lung abscess.
· Infections of skin and soft tissue: abscesses (including retropharyngeal, breast), abscess, cellulitis, infected wounds, cellulitis.
· Urinary and urogenital tract infection including sexually transmitted infections: cystitis, urethritis, pyelonephritis, gonorrhea, chancroid (chancroid), septic abortion, puerperal sepsis, pelvic infections, salpingitis, salpingo-oophoritis, ovarial abscess, endometritis, bacterial vaginitis, pelvioperitonit.
· Infections of bones and joints: ostemielit, odontogenic infection.
· Mixed infections caused by gram-positive, gram-negative and anaerobic microorganisms: peritonitis, cholangitis, cholecystitis, complications after operations on abdominal organs, infection of the abdominal cavity (intraperitoneal sepsis), septicemia.
How Augmentin oral is taken?
Augmentin generic comes in the form of tablets 375mg (250mg of Amoxicillin and 125mg - clavulonate potassium), 625mg (500mg of Amocixillin and 125mg of Clavulonate potassium) and 1000mg (875mg of Amoxicillin and 125mg of Clavulonate potassium). Tablets are taken orally swallowing whole with sufficient amount of water. Try to take the medication with food. This will help to maintain an even level of the medication in the blood. It is very important that you finish your course of Augmentin, even if you start feeling better.
Which are Augmentin generic contraindications?
Augmentin oral is contraindicated for use in patients with:
· Hypersensitivity to penicillins, other beta-lactam antibiotics (risk of anaphylactic shock).
· With infectious mononucleosis and lymphatic leukemia because of high risk of skin rash
· Severe liver diseases including hepatic failure, cirrhosis
· Severe kidney diseases including renal failure, pyelonephritis, glomerulonephritis
· Phenylketonuria
· Pregnancy (Augmentin is a pregnancy category B meaning that it is not safe to use the medication during pregnancy because of insufficient studies about safety Augmentin in pregnant women)
· Breastfeeding
Augmentin should be used with caution in:
· Allergic diathesis
· Asthma
· Hives
· Pollinosis.
In some cases Augmentin may cause yeast infection. Let your health care provider know if you develop yeast infection or thrush during the treatment.
Augmentin is not indicated for the treatment of infections caused by fungi and viruses.
Which are Augmentin side effects?
The combination of amoxicillin and clavulanic acid is well tolerated by patients. The most common side effects include:
Gastrointestinal tract: dyspepsia, nausea, vomiting, diarrhea, dyspepsia. These side effects can be prevented if you take the medicine with food.
In very rare cases - candidiasis, pseudomembranous colitis, allergic reactions (urticaria or erythematous rash, erythema multiforme, exfoliative dermatitis, anaphylactic reactions), transient leucopenia (including neutropenia and agranulocytosis), thrombocytopenia and hemolytic anemia.
In rare cases the medication may cholestatic jaundice, hepatitis, interstitial nephritis. Sometimes there
Is moderate increase in the level of AST/ALT and alkaline phosphatase
How Augmentin oral can interact with other medicines?
- Indirect anticoagulants: simultaneous application with amoxicillin may increase the prothrombin time.
- Antacids containing aluminum, magnesium hydroxide, H2-histamine blockers (cimetidine, ranitidine), M-choline blockers (pirenzepin)
- Diuretics, probenecid, allopurinol, phenybutasone, NSAID's drugs may supress tubular secretion and increase the concentration of amoxicillin
- Allopurinol: simultaneous use increases the risk of developing skin rashes, exanthema (the mechanism of this phenomenon is still not clear).
- Methotrexate: the simultaneous application enhances the toxicity of methotrexate.
- Amoxicillin may weaken the effect of oral contraceptives, ethinyl estradiol.
- Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) enhance the effects of Augmentin, bacteriostatic antibiotics (macrolides, chloramphenicol, Lincosamides, tetracyclines, sulfonamides) possess antagonistic effects. Avoid alcohol drinking during the treatment with Augmentin.
How the medication should be stored?
Store the medication at dry and protected from light place at room temperature out of reach of children.
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