Cipro. Generic Cipro (Ciprofloxacin oral). Buy Ciprofloxacin oral
What is generic Cipro?
Ciprofloxacin oral is a broad spectrum bactericidal antibiotic which acts both on gram-positive and gram-negative microorganisms. Ciprofloxacin is successfully used to treat systemic infections (with the exception CNS infections) which are caused by sensitive to the medication ingredients: infections of the respiratory system, ENT infections, gynecological infections, sexually transmitted infections including gonorrhea, infections of the abdominal cavity and gastrointestinal tract. Ciprofloxacin is the most used antibacterial remedy in clinical practice. Ciprofloxacin is made by Indian manufacturer Ranbaxy.
How does Ciprofloxacin oral works?
The active ingredient of generic Cipro is Ciprofloxacin which belongs to a group of antibiotics called fluroquinolone or quinolones. Like other quinoline antibiotics Ciprofloxacin oral acts by blocking DNA-gyrase (topoisomerase). Topoisomerase is an enzyme which regulates and controls the synthesis of bacterial proteins. By inhibiting DNA-gyrase Ciprofloxacin interferes with the production of bacterial proteins. Ciprofloxacin exerts bactericidal action on microorganisms being in resting conditions or dividing state.
The spectrum of antibacterial activity includes gram-positive and gram-positive microorganisms: Listeria, Corynebacterium, E.coli,Shigella, Acinetobacter, Brucella, Sreptococcus agalactiae, Chlamydia, Branhamella, Staphylococcus, Pasteurella, Haemophilus, , Enterobacter, Serratia, Hafnia, Salmonella, Citrobacter, Klebsiella, Edwardsiella, Proteus (indole-positive and indole-negative), Providencia,Morganella, Neisseria,Moraxella, Yersinia, Vibrio, Aeromonas, –lesiomonas, Campylobacter, Pseudomonas, Legionella.
Ciprofloxacin is effective against bacteria which produce beta-lactamases. The sensitivity to ciprofloxacin varies in: Mycoplasma hominis, MycobaŮterium tuberculosis, Mycobacterium fortuitum, Streptococcus viridans, Gardnerella, Flavobacterium, Streptococcus pyogenes, Streptococcus pneumonia, Alcaligenes, Streptococcus faecali.
The following microorganisms are resistant to generic Cipro: Nocardia asteroids, Streptococcus faecium, Ureaplasma urealyticum
Anaerobic microorganisms are moderately sensitive to Ciprofloxacin (Peptococcus,Peptostreptococcus) or resistant (Bacteroides). Ciprofloxacin does not act on Treponema pallidum and fungi. The resistance to Cipro generic is developed gradually and slowly.
Ciprofloxacin oral is active against pathogens which are resistant to beta-lactam antibiotics, aminoglycosides and tetracyclines. The medication does not change intestinal and vaginal microflora.
Which is Ciprofloxacin pharmacokinetics?
Ciprofloxacin is well and rapidly absorbed into the blood circulation after oral administration (the bioavailability is 70-80%). Maximal concentration in the plasma is achieved in 60-90min. The distribution volume is 2-3l/kg. Only 20-40% of the indicated dosages bind to plasma proteins. Ciprofloxacin penetrates in organs and tissues. Ciprofloxacin is eliminated out of the organism in unchanged form with urine. Half life period is 3-5 hours. A small amount of medication is eliminated with bile and faeces.
What is Ciprofloxacin used for?
Generic Cipro is used to treat complicated and uncomplicated infections caused by sensitive to the medication microorganisms (bacteria):
· Respiratory tract infections. Ciprofloxacin is indicated for the pneumonia caused by Haemophilus influenza, Legionella, staphylococcus Klebsiella eg, enterobacteria, bacteria genus Pseudomonas, , bacteria genus Branhamella,
· Infection of the middle ear and paranasal sinuses, especially if they are caused by Gram-negative bacteria, including bacteria genus Pseudomonas, and staphylococci;
· Eye infection
· Typhoid Fever (Enteric Fever) caused by Salmonella typhi.
· Infection of the kidneys and urinary tract
· Infections of the skin and soft tissue
· Infections of bones and joints
· Infection of the pelvic organs (including adnexitis and prostatitis)
· Digestive system infections
· Infections of the locomotor system
· Infection of the gall bladder and biliary tract
· Acute Uncomplicated Cystitis in females
· Infectious diarrhea
· Prevention and treatment of infections in patients with weak immunity (the treatment with immunosuppressants and in neutropenia)
· Selective intestinal decontamination on the background of immunosuppressive therapy.
How Ciprofloxacin oral is taken?
Ciprofloxacin tablets should be taken exactly as prescribed by your doctor. Do not use the medication without consultation with your physician. Ciprofloxacin tablets are taken orally with sufficient amount of water swallowing whole. Do not crash, chew or split the tablets. You should not stop taking the medicine if you start feeling better. Seek immediate medical attention if you develop tendon damage, severe allergic reactions.
When Cipro should not be taken?
· Pseudomembranous colitis
· Children (under 18 years of age)
· Hypersensitivity to ciprofloxacin and other quinolone antibiotics
· Low potassium blood levels
· Epilepsy or seizures
· Pregnancy (Levofloxacin is a pregnancy category C meaning that is unsafe to the drug during pregnancy)
· Breastfeeding (levofloxacin can pass through breast milk). Therefore the medication should be avoided in breastfeeding mothers
Ciprofloxacin oral should be used with caution in:
· Atherosclerosis of the cerebral blood vessels
· Disorders of the brain circulation
· Psychotic diseases
· Liver failure
· Prolonged QT interval
· Reactions of hypersensitivity
· Renal insufficiency (renal failure)
· Elderly age
Cipro special cautions
· Cipro can cause severe side effects. Seek immediate medical attention if you notice any side effects associated caused by ciprofloxacin. Make sure to let your health care provider know if you noticed any signs of liver damage such as jaundice, yellowing of the skin and eyes.
· Like all quinolones CIpro tablets can cause tendon damage. In most cases it involves the Achilles tendon, and rupture of the Achilles tendon may require surgical interventions.
· Patients over 60 years of age which had the transplantation of organs are at high risk of tendon damage
· Cipro drug may cause some disorders of central nervous system (Cipro side effects)
· Cipro tablets may cause the damage of the nerves
· The medicine can affect the heart rhythm
· Overuse of antibiotic may lead to development of superinfection and yeast infection
· The medication can initiate seizure attacks
· Do not drive or operate any machinery while the treatment with the medication.
Which Cipro side effects are possible while the treatment?
In most cases the medication is well tolerated and does not cause significant side effects (when is used in recommended doses). However, during the clinical trials it were observed the following side effects:
· Digestive system: nausea, vomiting, diarrhea, abdominal pain, flatulence, anorexia, cholestatic jaundice (especially in patients with liver disease in anamnesis), hepatitis, hepatic necrosis.
· Central nervous system: dizziness, photophobia, insomnia, paresthesia, irritability, headache, fatigue, anxiety, tremors, "nightmarish" dreams, peripheral paralgesia, increased intracranial pressure, confusion, depression, hallucinations, as well as other manifestations of psychotic reactions, migraine, syncope, thrombosis of cerebral arteries.
· Sense organs: changes of taste and smell, visual disturbances (diplopia, changes in vision color), tinnitus, hearing loss.
· Cardiovascular system: tachycardia, cardiac arrhythmia, decrease or increase of blood pressure, seizures, angina, myocardial infarction.
· Hematopoietic system: eosinophilia, leukopenia, granulocytopenia, anemia, thrombocytopenia, leukocytosis, thrombocytosis, hemolytic anemia.
· Laboratory parameters: hypoprotrombinemia, increased activity of "liver" transaminases, hypercreatininemia, hyperbilirubinemia, and hyperglycemia which may increase the content of alkaline phosphatase and lactate dehydrogenase.
· Urogenital system: hematuria, crystalluria (especially with alkaline urine and low diuresis), glomerulonephritis, dysuria, polyuria, urinary retention, albuminuria, urethra bleedings, reducing nitrogen eliminating renal function, acute renal insufficiency caused by interstitial nephritis.
· Allergic reactions: skin itching, rash, fever, pinpoint hemorrhages on the skin, swelling of face, lips or throat, shortness of breath, eosinophilia, increased photosensitivity, vasculitis, nodular erythema, exudative erythema multiforme, malignant exudative erythema multiforme (Stevens-Johnson syndrome) , toxic epidermal necrolysis (Lyell syndrome).
· Other: arthralgia, arthritis, tendon ruptures, general weakness, myalgia, super-infection (candidiasis, pseudomembranous colitis).
Which are Ciprofloxacin overdose symptoms?
In cases of overdose Ciprofloxacin may cause renal toxicity. In cases of Cipro overdose symptomatic treatment is required:
· Inducing vomiting or gastric lavage
· Administration of antacids
· Fluid therapy
How Ciprofloxacin can interact with other drugs?
You should inform your doctor if you take prescription and non-prescription drugs, minerals, vitamins, herbal supplements.
· Simultaneous use of theophylline and Ciprofloxacin results in increase of its concentration in blood plasma, so it is necessary to adjust theophylline dosing regimen.
Cipro enhances nephrotoxicity in cyclosporine, leading to increased levels of creatinine.
· Simultaneous use of nonsteroidal anti-inflammatory drugs (NSAID's) and generic Cipro may increase the risk of Cipro side effects on central nervous system.
Concomitant application with probenicide (or other drugs that block tubular secretion) leads to a decrease in renal excretion of ciprofloxacin.
· Metoclopramide accelerates the absorption of ciprofloxacin
· Ciprofloxacin increases a half life periods of xantines and hypoglyecemic drugs
· In concomitant application with antacids containing magnesium hydroxide or aluminum hydroxide the absorption of ciprofloxacin is reduced.
· Cipro generic enhances the effects of oral blood thinners (anticoagulants such as Warfarin)
· The drug enhances the effects of glibyride and may cause significantly low blood sugar levels
· Cipro may enhance the effects of other antibiotics (beta-lactam, aminoglycosides, cephalosporins).
· The medication may also interacts with: tizanidine (Zanaflex®), tricyclic antidepressants, phenytoin, antiarrhythmics, nti-psychotic medicine, diuretics, steroids, corticosteroids, methotrexate, sucralfate, didanosine
How the medication should be stored?
You should store the medication at dry and protected from light place out of reach of children. Keep the medication at room temperature.
Where can I buy Ciprofloxacin online?
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What is the manufacturer of generic Cipro?
The medication is made by Ranbaxy which is a well known drugs manufacturer