Doxycyline - Rx (prescription only drug).

Order doxycycline online. Doxycycline made by Cipla. Doxicip 100

What is Doxycycline?

Doxycycline is a semisynthetic bacteriostatic antibiotic that belongs to a group of tetracycline antibiotics. Doxycycline posesses a broad spectrum of antibacterial activity. It works by inhibiting protein synthesis in the microbial cell at the ribosomal level. Doxycycline acton intracellularly located pathogens (mycoplasma, chlamydia, rickettsia). It is actively used against infectious and inflammatory diseases caused by susceptible microorganisms, especially intracellular pathogens: ENT infections, infections of the respiratory, biliary and gastrointestinal tract, urogenital system, skin and soft tissues, bones and joints, infectious diseases of the eye. It is effective against mycoplasma, chlamydia, pertussis, syphilis, gonorrhea, brucellosis, fever, dysentery, yersiniosis, tularemia, cholera, actinomycosis, leptospirosis, trachoma, psittacosis, ornithosis, erlihioze, malaria, etc.

Doxycyclone comes in the form of capsules containing Doxycycline hydrochloride 100mg made by Indian manufacturer Cipla under the commercial name Doxicip 100.

What is Doxycycline action mechanism and spectrum of activity?

Doxycycline is a semisynthetic broad-spectrum antibiotic of tetracycline group. Doxycycline posesses bacteriostatic action by penetrating into the bacterial cell. Action mechanism is associated with Doxycycline interferes with the connection of transport aminoacyl-RNA to 30S ribosomal subunit and thus inhibits protein synthesis in the microbial cell at the ribosomal level. Antibacterial spectrum of Doxycycline is similar to tetracycline.

Doxycycline is active against Gram-positive microorganisms: Aerobic cocci: Staphylococcus spp., Including Staphylococcus aureus, Staphylococcus epidermidis (including penicillinase-producing), Streptococcus spp., Including Streptococcus pneumoniae. Aerobic spore-forming bacteria: Bacillus anthracis. Aerobic asporogenous bacteria: Listeria spp., Including Listeria monocytogenes. Anaerobic spore-forming bacteria: Clostridium spp. Doxycycline is active against Gram-negative microorganisms: Aerobic cocci: Neisseria gonorrhoeae, Neisseria meningitidis. Aerobic bacteria: Escherichia coli, Shigella spp., Salmonella spp., Yersinia spp., Enterobacter spp., Entamoeba histolytica, Klebsiella spp., Bordetella pertussis, Haemophilus influenzae, Pasteurella spp., Bacteroides spp. Doxycycline is also active against Rickettsia spp., Treponema spp. , Mycoplasma spp. and Chlamydia spp. Haemophilus influenzae (91-96%) and intracellular pathogens (Chlamydia, mycoplasma, rickettsia) are the most susceptive to doxycycline.

Doxycycline is active against most dangerous infectious diseases: plague, tularemia, anthrax germs, Legionella, Brucella, cholera, glanders germs, pathogens ornithosis, psittacosis, trachoma, venereal granuloma. Doxycycline is used to treat malaria in combination with Quinine. Pseudomonas aeruginosa, Proteus spp., Serratia spp., most strains of Bacteroides fragilis, fungi are resistant to doxycycline. There is cross-resistance to other tetracyclines.

Which are Doxycycline pharmakokinetic characteristics?

After oral administration Doxycycline is almost completely absorbed from the gastrointestinal tract into the blood circulation. It has a high degree of lipid solubility and meal has no significant effect on the absorption degree. The maximum concentration in plasma usually is determined in 2 hours after administration. Doxycycline Binds to plasma proteins by 80-95%. Doxycycline is widely distributed in tissues and body fluids. Therapeutic concentrations are found in bile, exudates maxillary and frontal sinuses, pleural and ascitic fluid, synovial exudate. In therapeutic concentrations it is accumulated in bones, liver, kidneys, spleen, prostate gland, eyes tissue. It forms insoluble complexes with calcium in bones and teeth. The half-life (T1 / 2) period after a single oral doseis 16-18 hours, after receiving repeated doses - 22-23 hours. Approximately 40% received Doxycycline dose is secreted by renal tubules with urine. 20-60% of doxycycline are excreted in the faeces as inactive forms (chelates). Hemodialysis and peritoneal dialysis does not affect the level of doxycycline in serum.

When Doxicip 100 is prescribed?

Doxycycline is used to treat infectious diseases caused by susceptible microorganisms, especially intracellular pathogens (Mycoplasma spp., Chlamydia spp., Rickettsia spp.) and Haemophilus influenzae:

• Infection of lower respiratory tract and lungs (bronchitis, pneumonia, lung abscess, pleurisy, empyema)

• ENT infections (tonsillitis, pharyngitis, sinusitis, otitis media);

Infections of the biliary and gastrointestinal tract (cholecystitis, cholangitis, peritonitis, proctitis, periodontitis, enterocolitis)

• Infection of the urogenital system (pyelonephritis, cystitis, urethritis, pelvic infection, endometritis, endocervicitis, prostatitis, epididymitis)

• Infections of skin and soft tissue (acne, cellulitis, abscesses, furunculosis, whitlow, infected burns and wounds)

• Infections of bones and joints (osteomyelitis, bursitis)

• Sepsis, bacterial endocarditis • Infectious diseases of the eye (keratitis, conjunctivitis) •Mycoplasmosis

• Chlamydia

• Whooping cough

• Syphilis

• Gonorrhea

• Chancroid

• Inguinal granuloma

• Brucellosis

• Fever

• Typhus

• Q fever

• Rocky Mountain spotted fever

• Trench fever

• Traveler's diarrhea

• Dysentery (bacillary and amoebic)

• Cholera

• Yersiniosis

• Plague

• Tularemia

• Lyme disease (early stage)

• Actinomycosis

• Leptospirosis

• Trachoma

•Psittacosis

• Malaria (in combination with quinine)

How Doxycycline is taken?

Doxycycline hydrochloride comes in the form of capsules which should be taken orally (by mouth) swallowing whole with a glass of water. You should take the medication exactly as prescribed by your doctor. Try to take the medication with food at the same time each day.

Which are doxycycline contraindications?

Doxycycline should not be used in the following conditions:

• Individual intolerance (including a history of hypersensitivity) of doxycycline or other tetracyclines;

• Porphyria

• Severe hepatic impairment

• Leukopenia

• Period of tooth development - 8-9 years of age

• Pregnancy (especially II and III trimesters)

• Breastfeeding

• Myasthenia gravis Doxicip should be used with caution in:

• Hepatic impairment

• Severe renal insufficiency

• Systemic lupus erythematosus.

Using Doxycycline during pregnancy and lactation:

Doxycycline is contraindicated for use during pregnancy. It can penetrate through the placental barrier and cause permanent discoloration of teeth, enamel hypoplasia, inhibition of bone growth of the fetus. The medication exerts mutagenic effects. Doxycycline is determined in breast milk in quantities that make up 30-40% from its level in serum. Therefore the use of the medication during breastfeeding should be avoided.

In prolonged use you should regularly monitor your blood picture levels. Many tetracyclines have been known to cause pseudomembranous colitis. If you notice such symptoms, make sure to contact your doctor immediately.

Which doxycycline side effects are possible during the treatment?

• Nervous system: dizziness, increased intracranial pressure (nausea, vomiting, headache, papilledema).

• Digestive system: nausea, vomiting, anorexia, abdominal pain, diarrhea or constipation, dysphagia, stomatitis, glossitis, esophagitis, erosive and ulcerative lesions in gastrointestinal tract, proctitis, candidiasis development, intestinal dysbiosis, pseudomembranous colitis, increased levels of hepatic transaminases in the blood (hepatotoxicity).

• Hemopoietic system: hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia.

• Allergic and dermatological reactions: skin rash, itching, urticaria, Quincke's edema, dyspnea, anaphylaxis, photosensitivity, exfoliative dermatitis.

Other: candidiasis, sweating, pericarditis, exacerbation of systemic lupus erythematosus; in children - changing the color of teeth, damage, delayed development of the skeleton. In case of severe adverse symptoms, the use of Doxycycline should be immediately discontinued.

How Doxicip 100 can interact with other medicines?

You should not Doxycycline simultaneously with antacids containing aluminum salts, calcium and magnesium (Phosphaluger, Maalox, Rennie et al), iron supplementation (iron salts, ferric hydroxide), sodium bicarbonate, magnesium containing laxatives (magnesium sulfate) Absorption of doxycycline is reduced in simultaneous use wuth cholestyramine and colestipol. Barbiturates, carbamazepine, phenytoin, rifampin, and other inductors of microsomal oxidation accelerates the metabolism of doxycycline and reduce the period of its half-life due to the acceleration of metabolism in the liver. Doxycycline reduces prothrombin index and potentiates the effect of indirect anticoagulants (warfarin, fenilin, etc.).

Doxycycline reduces the effectiveness of bactericidal antibiotics that act on bacterial cellular wall. Doxycycline hydrochloride reduces the effect of penicillins (benzylpenicillin, benzathine benzylpenicillin, oxacillin, amoxicillin, amoxicillin and clavulanate), cephalosporins (cefazolin, cefuroxime, cefotaxime, cefepime, ceftriaxone, ceftazidime, cefoperazone, cephalexin, cefixime, cefaclor).

Doxycycline reduces the effectiveness of oral birth control pills and increases the risk of bleedings. Simultaneous application with retinol leads to increased intracranial pressure. Doxycycline enhances the action of antidiabetic drugs: sulfonylurea derivatives (glibenclamide, glipizide, glimepirid). Doxycycline enhances the effects of nephrotoxic drugs.

Doxycycline hydrochloride increases the toxicity of methotrexate and cyclosporine A. The medication can also increase the risk of gastrointestinal side effects when used in combination with theophylline.

How the medication should be stored?

You should store Doxicip at room temperature out of reach of children. Avoid direct sunlight during storage.

Where can I order Doxycycline online?

You can order Doxycycline online at our online pharmacy. We provide high quality doxycycline made by Cipla under the commercial name Doxicip 100.

How can I order Doxycycline online?

You can order Doxycycline online using your Visa/Visa Electron card and E-check.