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What is Cetirizine hydrochloride? Cetirizine is a blocker of the peripheral histamine H1-receptor, antihistamine preparations, hydroxyzine metabolite. Cetirizine hcl inhibits histamine-dependent early phase of an allergic reaction and prevents various physiological and pathophysiological effects caused by histamine such as delation and increased permeability of capillaries (the development of edema, hives, redness), stimulation of sensory nerve endings (itching, pain) and contraction of the smooth muscle of the respiratory and gastrointestinal tract. At later stage of allergic reaction Cetirizine hydrochloride inhibits the release of histamine and migration of eosinophils and other cells. Cetirizine reduces the expression of adhesion molecules such as ICAM-1 and VCAM-1, which are markers of allergic inflammation, inhibits the activity of other mediators and inducers of histamine secretion such as PAF (platelet-activating factor) and substance P. Cetirizine hcl significantly reduces hyperreactivity of bronchial tree, occurring in response to the release of histamine in patients with bronchial asthma. These effects are not accompanied by cetirizine central action. Cetirizine inhibits skin reactions in patients suffering from cold urticaria and dermographism. The medication does not possess anticholinergic and anti-serotonin action. The use of cetirizine at therapeutic doses of 10 mg/dailyimproved the quality of life in patients with perennial and seasonal allergic rhinitis. The indication of high-dose cetirizine (60 mg/daily) revealed no pololong QT interval on ECG. The effects of cetirizine hydrochloride starts in 20 minutes after taking the drug, the maximum antihistaminic effect is achieved after 1 hour. Cetirizine acts for 24 hours meaining that it is sufficient to take 1 tablet daily to achieve maximal therapeutic effect.
What is Cetirizine hydrochloride used for? Symptomatic treatment of adults and children older than 5 years of age: · Seasonal and perennial allergic rhinitis, pollinosis · Allergic conjunctivitis · Chronic idiopathic urticaria · Angioedema (Quincke's edema) · Itching · Complex therapy of atopic dermatitis, chronic eczema, bronchial asthma (in combination with other drugs)What is Cetirizine hcl dose? Cetirizine comes in the form of oral tablets Cetirizine hcl 10mg, and 5mg. Cetirizine oral tablets are taken orally swallowing with sufficient amount of water before or after meal. Try to take the medication at the same time each day. The medication can cause drowsiness in some patients and that is why it is recommended to take in the evening. The recommended dose for adults is 10mg once daily. When Cetirizine hydrochloride is contraindicated? Cetirizine hcl is contraindicated in patients with hypersensitivity or known allergic reactions to any of the medication ingredients. The medication is also contraindicated for pregnant and breastfeeding women, children under 6 years of age. Zyrtec is a pregnancy category B meaning that is probably safe to use it during pregnancy. However, the full risk is unknown. Please consult your doctor if you are pregnant or breastfeeding. Do not take Cetirizine hcl if you have severe liver or kidney disease. Special cautionsA smaller dose of cetirizine hcl should be used in patients with moderate renal insufficiency, patients on hemodialysis and with impaired liver function. The excretion of the medication is decreased and the dose in this category of patients should be adjusted. The medication must not be used in patients with chronic alcoholism.Which is Cetirizine hcl side effects? Cetirizine is generally well tolerated. Clinical studies of psychomotor function showed that the frequency of sedative action with cetirizine does not differ from its frequency in patients receiving placebo. In rare cases cetirizine may cause headache, dizziness, drowsiness, fatigue, dry mouth, excitement, gastrointestinal disorders. Less common Cetirizine side effects include: weakness, nausea, vomiting, abdominal pain, diarrhea, constipation and increased appetite, increased activity of liver transaminases, hemolytic anemia, thrombocytopenia. Hypersensitivity reactions in the form of skin reaction and vascular edema are extremely rare. How Cetirizine hydrochloride may interact with other medicines? Cetirizine may enhance the the effects of medicines that causes drowsiness. This list include: · Anxiety medications · Narcotic pain killers · Antidepressants · Antipsychotics · Antiemetics Theophylline may increase blood level of Cetirizine hydrochloride. Where can I buy Cetirizine hydrochloride?
You can buy the medication at our reliable online pharmacy. We guarantee high quality products from well known manufacturer. Cetirizine hcl is manufactured by Zydus under the name Citicard, it is also made by GSK under the brand name Zyrtec.
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