Cerebrolysin. All Cerebrolysin information
What is Cerebrolysin and how does this medication work?
Cerebrolysin is a nootropic drug which contains low molecular biologically active neruropeptides, which penetrate through blood-brain barrier and act directly on the nerve cells. The drug possesses a multimodal organo-specific effect on the brain, provides metabolic regulation, neuroprotection, functional neuro-modulation, and neurotrophic activity as well.
Metabolic regulation: Cerebrolysin improves the efficiency of aerobic energy metabolism in the brain, improves the intracellular protein synthesis in the developing and aging brain.
Neuroprotective effect: Cerebrolysin protects neurons (brain nerve cells) from the damaging effects of lactic acidosis, prevents the formation of free radicals, increases survival and prevents neuronal death during hypoxia and ischemia, reduces the damaging neurotoxic effect of certain amino acids (glutamate).
Neurotrophic activity: Cerebrolysin is the only peptide containing nootropic drug with proven neurotrophic activity similar to the action of a neuronal growth factor (NGF).
Functional neuromodulation: the medication possesses a positive effects in patients with cognitive impairment, for concentration improvement and memory problems.
Which are Cerebrolysin Pharmacokinetics characteristics?
Cerebrolysin has a complex composition which contains a mixture of biologically active oligopeptides which exert poly-functional action. Finally this does not allow to carry a Pharmacokinetic analysis of individual components.
When the medication is prescribed?
Cerebrolysin is prescribed in the following conditions:
- Complex therapy of endogenous depression (in combination with psychotherapy and antidepressants)
- Post-apopletic complications
- Chronic cerebrovascular disorders
- Brain and spinal cord injuries (craniocerebral trauma, post operative trauma, concussion, cerebral contusion,)
- Alzheimer disease
- Ischemic stokes (treatment the complications)
- Mental retardation
- Senile dementia
How the medication is used?
The drug is used parenterally. The dose of duration of treatment depends on the disease you treat and severity of the disease, patients. The medication is used as intra-venous and intra-muscular injections which should be made only by a medical staff. If you need the recommended doses of the medicine consult our customer support. Any medication information available on the website or provided by our customer support is for informational purposes only.
Which side effects are possible with Cerebrolysin?
In excessively rapid injections: in cases rare the medication may cause feeling the heat, sweating, dizziness, tachycardia or fibrillation.
- Digestive system: loss of appetite, indigestion, diarrhea, constipation, nausea and vomiting.
- Central nervous system and peripheral nervous system: rarely - excitement, vaggressive behavior, confusion, insomnia, seizures, convulsions.
- Allergic reactions: hypersensitivity reactions, headache, pain in the neck, legs, lower back, shortness of breath, chills and collaptoid state.
- Local reactions: hyperemia of the skin, itching and burning at the injection site.
- According to the results of clinical studies there were reported the following Cerebrolysin side effects:
- Cardiovascular system: hypertension, hypotension.
- Central nervous system and peripheral nervous system: fatigue, tremor, depression, apathy, dizziness.
- Other: hyperventilation, influenza-like symptoms (cough, runny nose, respiratory tract infections).
Note that some Cerebrolysin side effects (agitation, hypertension, hypotension, lethargy, tremors, depression, apathy, dizziness, headache, shortness of breath, diarrhea, nausea) were identified during clinical trials and occurred equally in patients, receiving Cerebrolysin , and patients taking placebo.
Which are Cerebrolysin contraindications?
- Acute kidney insufficiency
- Epileptic status
- Known hypersensitivity to any of the drug ingredients
The medication should be used with caution in I trimester of pregnancy and during breastfeeding. The application of medicines during pregnancy and breastfeeding is possible only in case when the estimated benefit for mother overweighs potentional risk for the fetus. There were no conducted clinical studies which could determine negative effects of Cerebrolysin for the fetus.
The medication is contraindicated in patients with acute renal failure.
In excessively rapid implementation of injections a patient may develop fever, sweating, dizziness. Therefore, the drug should be administered slowly.
The medication can be used along with the following standard solutions for infusion: 0.9% sodium chloride, Ringer's solution, 5% solution of dextrose (glucose).
The medication can simultaneously be used Cerebrolysin ® with vitamins and drugs, improving blood circulation. However these drugs should not be mixed in one syringe with Cerebrolysin ®. You should use only the clear solution of the medication .
Clinical trials have shown that Cerebrolysin ® does not affect the ability to drive vehicles and use machinery.
There are no reported any cases of overdose side effects caused by this medication. Do not exceed the recommended dose.
How the medication can interact with other medicines?
Cerebrolysin may enhance the effects of antidepressants and MAO inhibitors in concomitant use. The drug is not compatible with lipid containing solution and solutions which change pH. The medication should not be mixed with aminoacids solution.
How the medication should be stored?
The preparation should be stored out of reach of children, protected from light place at temperature not more than 25°C. Expiration date is 5 years (for vials) and 4 years (for flasks).