Ranitidine 150mg tab. Ranitidine 300mg. Ranitidine hcl oral
What is Ranitidine?
Ranitidine is a second generation H2-histamine receptor blocker with a potent specific affinity to parietal cells of the stomach and possesses gastroselective action. The medication affects the main cause of heartburn and indigestion, normalizing the process of stomach acid production. Ranitidine is considered to be the gold standard in the treatment of gastric and duodenal ulcers (including stress ulcer, NSAID-gastropathy, Zollinger-Ellison syndrome). Ranitidine hcl comes in the form of oral tablets 150mg and 300mg made by Torrent Pharmaceuticals under the name Ranitin.
How does Ranitidine work?
Ranitidine hcl is highly active histamine H2-receptor of second generation. It possesses a strong and specific affinity for parietal cells exerting gastroprotective action. The main therapeutic effect of ranitidine is based on reducing the overproduction of hydrochloric acid by the stomach. Ranitidine hcl oral inhibits both basal and stimulated by histamine, gastrin, pentagastrin and acetylcholine secretion of hydrochloric acid, decreases the volume of gastric juice and concentration of hydrogen ions. It also reduces the activity of pepsin. In addition, ranitidine hcl oral inhibits degranulation of mast cells, reduces the content of histamine in periacinar zone, and stimulates the process of ulcer healing by increasing the amount of DNA-synthesizing epithelial cells.
Ranitidine stimulates the tonicity of the lower esophageal sphincter. This can help prevent the reflux of acid and peptic stomach contents into the esophagus.
Which is Ranitidne 150mg tablets pharmacokinetics?
Ranitidine is well absorbed into the blood circulation from the gastrointestinal tract. The bioavailability of ranitidine is 40-80%. The maximum plasma concentration is achieved in 1-3 hours after administration. Ranitidine binds to proteins by 15%. The half-life period of ranitidine ranges from 2 to 2.5 hours.
What is Ranitidine hcl used for?
Ranitidine 150mg, 300mg tablets are used to treat conditions associated with hyperproduction of stomach acid:
What is Ranitidine dose?
Ranitidine comes in the form of tablets 150mg and ranitidine 300mg. Ranitidine dosage depends on patient's age, particular medical condition treated concomitant diseases. Ranitidine tablets are taken by mouth once till four times daily with or without food. Patients with decreased kidney function require decreasing the indicated dose.
When Ranitidine hcl oral is contraindicated?
Ranitidine 150mg tabs are contraindicated in the following conditions:
Which Ranitidine hcl oral side effects are possible during the treatment?
Ranitidine 150mg is characterized by high safety profile. Ranitidine is well tolerated and the frequency of side effects is low and comparable with the placebo.
How Ranitidine 150mg can interact with other medicines?
Antacids and sucralfate may reduce the absorption of ranitidine 150mg. Ranitidine hcl oral minimally inhibits hepatic metabolism of coumarin derivatives, theophylline, diazepam, propranolol, glipizide, glyburide, metoprolol, midazolam, nifedipine. Ranitidine hcl oral may increase the effects of indirect anticoagulants.
How Ranitidine should be stored?
Ranitidine 150mg tablets should be stored at room temperature out of reach of children.
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